RBMXL2 antibody (Middle Region)

Catalog No. ABIN2779064

Product Details anti-RBMXL2 Antibody

Target: RBMXL2 (RNA Binding Motif Protein, X-Linked-Like 2 (RBMXL2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBMXL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SSRDGYSSRD YREPRGFAPS PGEYTHRDYG HSSVRDDCPL RGYSDRDGYG

Predicted Reactivity: Cow: 85%, Dog: 77%, Guinea Pig: 77%, Horse: 77%, Human: 100%, Mouse: 77%, Rabbit: 85%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against RBMXL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RBMXL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 392 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RBMXL2

Target: RBMXL2 (RNA Binding Motif Protein, X-Linked-Like 2 (RBMXL2))

Alternative Name: RBMXL2 (RBMXL2 Products)

Synonyms: HNRNPG-T antibody, HNRNPGT antibody, HNRPGT antibody, 1700012H05Rik antibody, Hnrnpg-t antibody, RBMX antibody, hnRNP G-T antibody, RNA binding motif protein, X-linked like 2 antibody, RNA binding motif protein, X-linked-like 2 antibody, RBMXL2 antibody, Rbmxl2 antibody

Background: The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. RBMXL2 has two RRM domains that bind RNAs. RBMXL2 has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility.This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2215 AC100875.3 67063-69277 c
Alias Symbols: HNRNPG-T, HNRPGT, HNRNPGT
Protein Interaction Partner: UBC, RABGGTA, FDXACB1, CAND1, COPS5, CUL1, CUL3, CUL4B, SUMO1, DYRK2, TRA2B,
Protein Size: 392

Molecular Weight: 43 kDa

Gene ID: 27288

NCBI Accession: NM_014469, NP_055284

UniProt: O75526