EIF2D antibody (Middle Region)

Catalog No. ABIN2779012

Product Details anti-EIF2D Antibody

Target: EIF2D (Eukaryotic Translation Initiation Factor 2D (EIF2D))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Dog, Horse, Pig, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF2D antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KVTVVRNLEA YGLDPYSVAA ILQQRCQAST TVNPAPGAKD SLQVQIQGNQ

Predicted Reactivity: Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against LGTN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LGTN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 584 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EIF2D

Target: EIF2D (Eukaryotic Translation Initiation Factor 2D (EIF2D))

Alternative Name: LGTN (EIF2D Products)

Background: LGTN is a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.
Alias Symbols: HCA56, LGTN
Protein Interaction Partner: UBC, AICDA, EIF1B, EIF1, HARS, DHX15, CUL3, HEXB, ACHE, RAD51,
Protein Size: 584

Molecular Weight: 65 kDa

Gene ID: 1939

NCBI Accession: NM_006893, NP_008824

UniProt: P41214