RBM14 antibody (N-Term)

Catalog No. ABIN2778973

Product Details anti-RBM14 Antibody

Target: RBM14 (RNA Binding Motif Protein 14 (RBM14))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM14 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YAFVHMEKEA DAKAAIAQLN GKEVKGKRIN VELSTKGQKK GPGLAVQSGD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RBM14. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RBM14

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 669 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-RBM14 antibody (ABIN2778973)

Sui, Yang, Xiong, Zhang, Blanchard, Peiper, Dynan, Tuan, Ko: "Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers." in: Oncogene, Vol. 26, Issue 6, pp. 822-35, (2007) (PubMed).

Target Details for RBM14

Target: RBM14 (RNA Binding Motif Protein 14 (RBM14))

Alternative Name: RBM14 (RBM14 Products)

Synonyms: im:7053198 antibody, wu:fc08a04 antibody, zgc:110682 antibody, sip antibody, coaa antibody, psp2 antibody, sytip1 antibody, tmem137 antibody, MGC52864 antibody, MGC132117 antibody, MGC75876 antibody, RBM14 antibody, RBM4 antibody, COAA antibody, PSP2 antibody, SIP antibody, SYTIP1 antibody, TMEM137 antibody, 1300007E16Rik antibody, Sytip antibody, p16 antibody, p16K antibody, CoAA antibody, rbm14 antibody, zgc:85696 antibody, RNA binding motif protein 14a antibody, RNA binding motif protein 14 L homeolog antibody, RNA binding motif protein 14 antibody, RNA binding motif protein 14b antibody, rbm14a antibody, rbm14.L antibody, rbm14 antibody, RBM14 antibody, Rbm14 antibody, rbm14b antibody

Background: RBM14 contains 2 RRM (RNA recognition motif) domains. Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.
Alias Symbols: COAA, DKFZp779J0927, SIP, SYTIP1, PSP2, TMEM137
Protein Interaction Partner: UBC, SUMO2, SUMO3, CEP250, DROSHA, MDM2, SMURF2, RPA3, RPA2, RPA1, EZH2, BMI1, RNF2, SUZ12, EED, MAPK15, CDK15, CDK14, HDAC9, HDAC11, WHSC1, VCAM1, TRAF3, ITGA4, FN1, ESR1, ZC3H18, FTSJ3, RBM25, TRMT112, HP1BP3, PRPF19, RBMX, RSL1D1, PRPF6, HNRNPH1, RCC1,
Protein Size: 669

Molecular Weight: 69 kDa

Gene ID: 10432

NCBI Accession: NM_006328, NP_006319

UniProt: Q96PK6

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway