SMNDC1 antibody (Middle Region)

Catalog No. ABIN2778955

Product Details anti-SMNDC1 Antibody

Target: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse, Goat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMNDC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: QFNNRAYSKN KKGQVKRSIF ASPESVTGKV GVGTCGIADK PMTQYQDTSK

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against SMNDC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SMNDC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 238 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMNDC1

Target: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Alternative Name: SMNDC1 (SMNDC1 Products)

Synonyms: smnr antibody, spf30 antibody, SMNDC1 antibody, SMNR antibody, SPF30 antibody, TDRD16C antibody, wu:fb37h07 antibody, wu:fc23a07 antibody, 2410004J23Rik antibody, 4933440I19Rik antibody, survival motor neuron domain containing 1 antibody, smndc1 antibody, SMNDC1 antibody, Bm1_41545 antibody, Smndc1 antibody

Background: This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene.
Alias Symbols: SMNR, SPF30
Protein Interaction Partner: UBC, PRPF3, SF3B5, SND1, CUL3, SF3A2, ELAVL1, HIST3H3, mad2, KPNB1, SNRNP200, SNRPB, CDK5RAP3, PPAN, TSR1, RNMTL1, SF3B1, SF3B3, SF3B2, SF3A3, SF3B4, DDX21, RUVBL1, RPL3, FDFT1, EWSR1,
Protein Size: 238

Molecular Weight: 27 kDa

Gene ID: 10285

NCBI Accession: NM_005871, NP_005862

UniProt: O75940