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SF3B4 antibody (N-Term)

SF3B4 Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Rabbit, Guinea Pig, Horse, Saccharomyces cerevisiae, Goat WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778952
  • Target See all SF3B4 Antibodies
    SF3B4 (Splicing Factor 3b, Subunit 4, 49kDa (SF3B4))
    Binding Specificity
    • 9
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 41
    • 20
    • 19
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Rabbit, Guinea Pig, Horse, Saccharomyces cerevisiae, Goat
    Host
    • 36
    • 5
    • 1
    Rabbit
    Clonality
    • 37
    • 5
    Polyclonal
    Conjugate
    • 25
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SF3B4 antibody is un-conjugated
    Application
    • 35
    • 24
    • 10
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    QDATVYVGGL DEKVSEPLLW ELFLQAGPVV NTHMPKDRVT GQHQGYGFVE
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 86%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against SF3B4. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human SF3B4
    Top Product
    Discover our top product SF3B4 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 424 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SF3B4 (Splicing Factor 3b, Subunit 4, 49kDa (SF3B4))
    Alternative Name
    SF3B4 (SF3B4 Products)
    Synonyms
    chunp6902 antibody, fb36a04 antibody, wu:fb36a04 antibody, 49kDa antibody, SF3b49 antibody, SF3b50 antibody, Sap49 antibody, spx antibody, AFD1 antibody, Hsh49 antibody, SAP49 antibody, Splicing factor 3B subunit 4 antibody, splicing factor 3b, subunit 4 antibody, splicing factor 3b subunit 4 S homeolog antibody, splicing factor 3b subunit 4 antibody, sap-49 antibody, sf3b4 antibody, Sf3b4 antibody, sf3b4.S antibody, SF3B4 antibody
    Background
    SF3B4 is one of four subunits of the splicing factor 3B. The protein cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.
    Alias Symbols: Hsh49, SAP49, SF3b49
    Protein Interaction Partner: NCK2, METTL17, ZCCHC10, UBASH3A, NUB1, HSPB7, PPP1R16B, SS18L1, HNRNPUL1, SF3B2, BAIAP2, SEC24D, FAM115A, RBM39, BAG3, CWF19L2, MAPK9, FUS, FRK, FKBP1A, STAU1, UBC, SUMO1, SUZ12, RNF2, PRPF40A, WBP4, APBB1, SRPK3, DDX42, PRPF8, CHERP, DDX17, BCAS2, EFTUD2
    Protein Size: 424
    Molecular Weight
    47 kDa
    Gene ID
    10262
    NCBI Accession
    NM_005850, NP_005841
    UniProt
    Q15427
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