HNRNPR antibody (N-Term)

Catalog No. ABIN2778950

Product Details anti-HNRNPR Antibody

Target: HNRNPR (Heterogeneous Nuclear Ribonucleoprotein R (HNRNPR))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNRNPR antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ANQVNGNAVQ LKEEEEPMDT SSVTHTEHYK TLIEAGLPQK VAERLDEIFQ

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HNRNPR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HNRNPR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 633 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HNRNPR antibody (ABIN2778950)

Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." in: Genome biology, Vol. 8, Issue 8, pp. R154, (2008) (PubMed).

Target Details for HNRNPR

Target: HNRNPR (Heterogeneous Nuclear Ribonucleoprotein R (HNRNPR))

Alternative Name: HNRNPR (HNRNPR Products)

Synonyms: hnrpr antibody, wu:fb97a09 antibody, wu:fe01h03 antibody, zgc:56523 antibody, HNRPR antibody, hnRNP R antibody, hnRNP-R antibody, 2610003J05Rik antibody, 2610528B01Rik antibody, Hnrpr antibody, heterogeneous nuclear ribonucleoprotein R antibody, hnrnpr antibody, HNRNPR antibody, Hnrnpr antibody

Background: HNRNPR belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif. Multiple alternatively spliced transcript variants have been found for this gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif. Multiple alternatively spliced transcript variants have been found for this gene.
Alias Symbols: FLJ25714, HNRPR, hnRNP-R, hnRNP R
Protein Interaction Partner: PRMT1, KHDRBS2, CEP250, SUMO2, IVNS1ABP, STAU1, UBC, MDM2, WWOX, ZBTB1, RPA3, RPA2, RPA1, RNF2, EED, rev, PPP4R1, MTA2, CCDC6, EHBP1L1, RABEP2, BRCC3, SMEK1, LSM8, LARP7, GAPVD1, CD2AP, WDHD1, SF3A1, TRIM28, HDAC1, NR3C1, POLR2C, POLR2A, MAP4, PARK2, SRPK
Protein Size: 633

Molecular Weight: 71 kDa

Gene ID: 10236

NCBI Accession: NM_005826, NP_005817

UniProt: O43390