HNRPDL antibody (C-Term)

Catalog No. ABIN2778938

Product Details anti-HNRPDL Antibody

Target: HNRPDL (Heterogeneous Nuclear Ribonucleoprotein D-Like (HNRPDL))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Zebrafish (Danio rerio), Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNRPDL antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YSGYGGYDYT GYNYGNYGYG QGYADYSGQQ STYGKASRGG GNHQNNYQPY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against HNRPDL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPDL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 420 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HNRPDL antibody (ABIN2778938)

Li, Johansson, Glahder, Mossberg, Schwartz: "Suppression of HPV-16 late L1 5'-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs." in: Nucleic acids research, Vol. 41, Issue 22, pp. 10488-508, (2013) (PubMed).

Anderson, Lin, Xiao, Stoilov, Burge, Black: "The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B." in: RNA (New York, N.Y.), Vol. 18, Issue 5, pp. 1041-9, (2012) (PubMed).

Target Details for HNRPDL

Target: HNRPDL (Heterogeneous Nuclear Ribonucleoprotein D-Like (HNRPDL))

Alternative Name: HNRPDL (HNRPDL Products)

Synonyms: wu:fa11d08 antibody, zgc:66169 antibody, hnRNP DL antibody, Hnrpdl antibody, AA407431 antibody, AA959857 antibody, D5Ertd650e antibody, D5Wsu145e antibody, JKTBP antibody, hnRNP-DL antibody, hnRNP antibody, hnrpdl antibody, hnrpdl-a antibody, jktbp antibody, jktbp2 antibody, laauf1 antibody, HNRNP antibody, HNRPDL antibody, JKTBP2 antibody, laAUF1 antibody, hnRNP D-like B antibody, hnRNP DL-B antibody, hnrnpdl-b antibody, hnrpdl-b antibody, heterogeneous nuclear ribonucleoprotein D-like antibody, heterogeneous nuclear ribonucleoprotein D like antibody, heterogeneous nuclear ribonucleoprotein D like L homeolog antibody, heterogeneous nuclear ribonucleoprotein D like S homeolog antibody, hnrpdl antibody, HNRNPDL antibody, Hnrnpdl antibody, hnrnpdl.L antibody, LOC100351670 antibody, LOC101120922 antibody, hnrnpdl.S antibody

Background: HNRPDL belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. HNRPDL has two RRM domains that bind to RNAs. Two alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein is similar to its family member HNRPD.
Alias Symbols: HNRNP, JKTBP, JKTBP2, laAUF1, HNRPDL
Protein Interaction Partner: SPRTN, SUMO2, SUMO3, UBC, RPA3, RPA2, RPA1, ERG, EED, RNF2, rev, PARK2, FBXO6, TARDBP, HMGA1, ITGA4, IL7R, IFIT3, IFIT2, FN1, CSNK2A1, BARD1, EEF2, EEF1A1, DDX3X, ATP6V1B1, HNRNPA3, WIPF2, RMDN3, MRPS16, UBE2S, LSM14A, RPL36, U2AF2, HNRNPUL1, HNRNPA0, HNR
Protein Size: 420

Molecular Weight: 46 kDa

Gene ID: 9987

NCBI Accession: NM_005463, NP_005454

UniProt: O14979