EIF4E2 antibody (N-Term)

Catalog No. ABIN2778915

Product Details anti-EIF4E2 Antibody

Target: EIF4E2 (Eukaryotic Translation Initiation Factor 4E Family Member 2 (EIF4E2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF4E2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: KDDDSGDHDQ NEENSTQKDG EKEKTERDKN QSSSKRKAVV PGPAEHPLQY

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against EIF4E2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EIF4E2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 245 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-EIF4E2 antibody (ABIN2778915)

Tee, Tee, Blenis: "Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1." in: FEBS letters, Vol. 564, Issue 1-2, pp. 58-62, (2004) (PubMed).

Target Details for EIF4E2

Target: EIF4E2 (Eukaryotic Translation Initiation Factor 4E Family Member 2 (EIF4E2))

Alternative Name: EIF4E2 (EIF4E2 Products)

Synonyms: 4E-LP antibody, 4EHP antibody, EIF4EL3 antibody, IF4e antibody, Eif4el3 antibody, EIF4E2 antibody, id:ibd1007 antibody, zgc:110542 antibody, zgc:158544 antibody, MGC115622 antibody, 2700069E09Rik antibody, AI036339 antibody, AV129531 antibody, D0H0S6743E antibody, eukaryotic translation initiation factor 4E family member 2 antibody, eukaryotic translation initiation factor 4E member 2 antibody, eukaryotic translation initiation factor 4E family member 2 L homeolog antibody, EIF4E2 antibody, Eif4e2 antibody, eif4e2 antibody, eif4e2.L antibody

Background: EIF4E2 belongs to the eukaryotic initiation factor 4E family. It recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Alias Symbols: 4EHP, IF4e, 4E-LP, EIF4EL3
Protein Interaction Partner: USHBP1, CARD9, PRDM14, HOMEZ, TRIM54, NECAB2, ADAMTSL4, AMOTL2, SPAG5, SPRY2, HUWE1, TMCC2, MAGED1, TCF4, TADA2A, TRIM27, REL, MYOG, KRT31, KRT19, KRT13, CDR2, AES, MAPRE3, NOTCH2NL, KRTAP10-8, KRTAP10-5, KRTAP10-9, ZBTB9, SPERT, USP54, MIPOL1, KRT40, UBX
Protein Size: 245

Molecular Weight: 27 kDa

Gene ID: 9470

NCBI Accession: NM_004846, NP_004837

UniProt: O60573

Pathways: SARS-CoV-2 Protein Interactome