STAU1/Staufen antibody (N-Term)

Catalog No. ABIN2778906

Product Details anti-STAU1/Staufen Antibody

Target: STAU1/Staufen (STAU1) (Staufen Double-Stranded RNA Binding Protein 1 (STAU1))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Horse, Cow, Guinea Pig, Dog, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAU1/Staufen antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NFEVARESGP PHMKNFVTKV SVGEFVGEGE GKSKKISKKN AAIAVLEELK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against STAU1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STAU1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 317 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for STAU1/Staufen

Target: STAU1/Staufen (STAU1) (Staufen Double-Stranded RNA Binding Protein 1 (STAU1))

Alternative Name: STAU1 (STAU1 Products)

Synonyms: STAU1 antibody, DKFZp459A0124 antibody, CG5753 antibody, Dmel\\CG5753 antibody, Dmstau antibody, STAU antibody, Stau antibody, Stauf antibody, dStau antibody, stau antibody, XStau antibody, XStau1 antibody, Staufen antibody, Staufen1 antibody, MGC145034 antibody, 5830401L18Rik antibody, AW549911 antibody, C85792 antibody, fi67e05 antibody, wu:fi67e05 antibody, zgc:77271 antibody, staufen double-stranded RNA binding protein 1 antibody, staufen antibody, RNA binding protein homolog antibody, staufen (RNA binding protein) homolog 1 (Drosophila) antibody, staufen double-stranded RNA binding protein 1 L homeolog antibody, STAU1 antibody, stau antibody, stau1 antibody, STAUFEN antibody, Stau1 antibody, stau1.L antibody

Background: STAU1(Staufen) is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.
Alias Symbols: STAU, FLJ25010
Protein Interaction Partner: LONRF1, GLRX3, ZMAT3, NXT1, SPRTN, MATR3, EIF4A3, NUP155, PRDX6, NPEPPS, DDX23, DDX21, AIFM1, INA, ATP6V0D1, SART1, RPL14, AP3D1, CPNE3, IQGAP1, PABPC4, EIF3D, EIF3B, EIF3A, PRKRA, KHSRP, IRS4, SLC25A11, SMC1A, PABPN1, DDX39B, TUBA1A, MOGS, YWHAZ, XPO1, V
Protein Size: 317

Molecular Weight: 35 kDa

Gene ID: 6780

NCBI Accession: NM_001037328

UniProt: O95793

Pathways: Asymmetric Protein Localization