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XPO1 antibody (C-Term)

XPO1 Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Zebrafish (Danio rerio), Rabbit, Pig, Saccharomyces cerevisiae WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778849
  • Target See all XPO1 Antibodies
    XPO1 (Exportin 1 (XPO1))
    Binding Specificity
    • 15
    • 10
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 71
    • 35
    • 34
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Horse, Zebrafish (Danio rerio), Rabbit, Pig, Saccharomyces cerevisiae
    Host
    • 66
    • 5
    Rabbit
    Clonality
    • 57
    • 14
    Polyclonal
    Conjugate
    • 38
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This XPO1 antibody is un-conjugated
    Application
    • 44
    • 16
    • 15
    • 14
    • 14
    • 13
    • 8
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    NKLGGHITAE IPQIFDAVFE CTLNMINKDF EEYPEHRTNF FLLLQAVNSH
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 93%
    Characteristics
    This is a rabbit polyclonal antibody against XPO1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human XPO1
    Top Product
    Discover our top product XPO1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1071 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Kalita, Kapinos, Zheng, Rencurel, Zilman, Lim: "Karyopherin enrichment and compensation fortifies the nuclear pore complex against nucleocytoplasmic leakage." in: The Journal of cell biology, Vol. 221, Issue 3, (2022) (PubMed).

  • Target
    XPO1 (Exportin 1 (XPO1))
    Alternative Name
    XPO1 (XPO1 Products)
    Synonyms
    CG13387 antibody, CRM1 antibody, Crm1 antibody, DCRM1 antibody, Dmel\\CG13387 antibody, Emb antibody, XPO-1 antibody, XPO1 antibody, Xpo1 antibody, crm1 antibody, dCRM1 antibody, l(2)k16715 antibody, 18.m06600 antibody, DDBDRAFT_0183812 antibody, DDBDRAFT_0234066 antibody, DDB_0183812 antibody, DDB_0234066 antibody, exportin-1 antibody, LOC100220104 antibody, emb antibody, exp1 antibody, Xpo antibody, AA420417 antibody, Exp1 antibody, embargoed antibody, exportin 1 antibody, putative exportin 1 antibody, chromosome region maintenance protein 1 antibody, exportin-1 antibody, exportin 1 (CRM1 homolog, yeast) antibody, exportin 1 S homeolog antibody, emb antibody, cgd3_3060 antibody, Tc00.1047053511725.150 antibody, Tb11.01.5940 antibody, BBOV_II007220 antibody, LMJF_32_1100 antibody, xpo1 antibody, Xpo1 antibody, XPO1 antibody, LOC100165622 antibody, LOC100633509 antibody, xpo1.S antibody
    Background
    XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. XPO1 also regulates NFAT and AP-1.The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: CRM1, DKFZp686B1823, emb, exp1
    Protein Interaction Partner: ABL1, UBC, HUWE1, ELAVL1, KEAP1, SUMO2, SUMO3, USP16, STAU1, CDC37L1, RNF2, rev, TUBB, SCPEP1, CAMK1D, DCPS, HSPA1L, HNRNPK, GNAI3, EEF2, CAPN2, TWF2, FERMT2, UBA3, NAE1, STK24, YWHAH, YWHAE, VCL, TUFM, PCYT2, PPP5C, PPP1CA, EGFR, LOC366310, CLN5, CLN3, S
    Protein Size: 1071
    Molecular Weight
    123 kDa
    Gene ID
    7514
    NCBI Accession
    NM_003400, NP_003391
    UniProt
    O14980
    Pathways
    M Phase
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