RDBP antibody (N-Term)

Catalog No. ABIN2778822

Product Details anti-RDBP Antibody

Target: RDBP (RD RNA Binding Protein (RDBP))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Guinea Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RDBP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LVIPPGLSEE EEALQKKFNK LKKKKKALLA LKKQSSSSTT SQGGVKRSLS

Predicted Reactivity: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%

Characteristics: This is a rabbit polyclonal antibody against RDBP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RDBP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 380 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-RDBP antibody (ABIN2778822)

Schulz, Brandner, Eberhagen, Eckardt-Schupp, Larsen, Andrae: "Quantitative phosphoproteomic analysis of early alterations in protein phosphorylation by 2,3,7,8-tetrachlorodibenzo-p-dioxin." in: Journal of proteome research, Vol. 12, Issue 2, pp. 866-82, (2013) (PubMed).

Target Details for RDBP

Target: RDBP (RD RNA Binding Protein (RDBP))

Alternative Name: RDBP (RDBP Products)

Synonyms: CG5994 antibody, Dmel\\CG5994 antibody, NELF antibody, NELF-E antibody, Nelf-e antibody, anon-66Da antibody, cg5994 antibody, dNelf-E antibody, D6S45 antibody, RD antibody, RDBP antibody, RDP antibody, Rd antibody, Rdbp antibody, D17H6S45 antibody, Negative elongation factor E antibody, negative elongation factor complex member E antibody, negative elongation factor complex member E, Rdbp antibody, Nelf-E antibody, NELFE antibody, Nelfe antibody

Background: RDBP is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins, however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D).The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins, however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: D6S45, NELF-E, RD, RDP, RDBP
Protein Interaction Partner: CCDC57, MTUS2, TRIM27, UBC, SRPK2, SRPK1, LMNA, POLR2C, SUMO1, NELFCD, NELFB, SF3B1, NELFA, TMEM141, RPAP2, WDR48, VAMP3, NCOR1, NELFE, POLR2A, CACTIN,
Protein Size: 380

Molecular Weight: 43 kDa

Gene ID: 7936

NCBI Accession: NM_002904, NP_002895

UniProt: P18615