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ISG20 antibody (N-Term)

ISG20 Reactivity: Human, Rat, Mouse, Dog, Horse, Cow, Pig, Guinea Pig, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778795
  • Target See all ISG20 Antibodies
    ISG20 (Interferon Stimulated Exonuclease Gene 20kDa (ISG20))
    Binding Specificity
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Rat, Mouse, Dog, Horse, Cow, Pig, Guinea Pig, Rabbit
    Host
    • 20
    • 5
    Rabbit
    Clonality
    • 22
    • 3
    Polyclonal
    Conjugate
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    This ISG20 antibody is un-conjugated
    Application
    • 24
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    GAVLYDKFIR PEGEITDYRT RVSGVTPQHM VGATPFAVAR LEILQLLKGK
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against ISG20. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human ISG20
    Top Product
    Discover our top product ISG20 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 181 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Zahoor, Xue, Sato, Murakami, Takeshima, Aida: "HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages." in: PLoS ONE, Vol. 9, Issue 8, pp. e106418, (2014) (PubMed).

    Horio, Murai, Inoue, Hamasaki, Tanaka, Ohgi: "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease." in: FEBS letters, Vol. 577, Issue 1-2, pp. 111-6, (2004) (PubMed).

  • Target
    ISG20 (Interferon Stimulated Exonuclease Gene 20kDa (ISG20))
    Alternative Name
    ISG20 (ISG20 Products)
    Background
    ISG20 belongs to the the exonuclease superfamily. It is exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. It degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. It is involved in the antiviral function of IFN against RNA viruses.
    Alias Symbols: CD25, HEM45
    Protein Interaction Partner: UBC,
    Protein Size: 181
    Molecular Weight
    20 kDa
    Gene ID
    3669
    NCBI Accession
    NM_002201, NP_002192
    UniProt
    Q96AZ6
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