EIF4B antibody (C-Term)

Catalog No. ABIN2778771

Product Details anti-EIF4B Antibody

Target: EIF4B (Eukaryotic Translation Initiation Factor 4B (EIF4B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Horse, Cow, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF4B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: NPPARSQSSD TEQQSPTSGG GKVAPAQPSE EGPGRKDENK VDGMNAPKGQ

Predicted Reactivity: Cow: 79%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against EIF4B. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EIF4B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 611 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-EIF4B antibody (ABIN2778771)

Suzuki, Fujisawa, Ando, Niino, Ohsawa, Shimokata, Ohta: "Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae." in: Neurology, Vol. 63, Issue 9, pp. 1711-3, (2004) (PubMed).

Target Details for EIF4B

Target: EIF4B (Eukaryotic Translation Initiation Factor 4B (EIF4B))

Alternative Name: EIF4B (EIF4B Products)

Synonyms: EIF-4B antibody, PRO1843 antibody, CG10837 antibody, Dm-eIF4B antibody, Dmel\\CG10837 antibody, Eif4B antibody, eIF-4B-L antibody, eIF-4B-S antibody, eIF-4b antibody, eIF4B antibody, eIF4B-L antibody, eIF4B-S antibody, eIf4b antibody, 2310046H11Rik antibody, AL024095 antibody, C85189 antibody, Eif4a2 antibody, eif4b antibody, fb15c09 antibody, wu:fb15c09 antibody, zgc:101532 antibody, MGC89384 antibody, eukaryotic translation initiation factor 4B antibody, eukaryotic initiation factor 4B antibody, Eukaryotic initiation factor 4B antibody, eukaryotic translation initiation factor 4Bb antibody, eukaryotic translation initiation factor 4Ba antibody, eukaryotic translation initiation factor 4B S homeolog antibody, EIF4B antibody, Eif4B antibody, eIF-4B antibody, Eif4b antibody, eif4bb antibody, eif4b antibody, eif4ba antibody, eif4b.S antibody, LOC100284982 antibody, LOC100380867 antibody

Background: IF4B contains 1 RRM (RNA recognition motif) domain and is required for the binding of mRNA to ribosomes. Functions of EIF4B are in close association with EEF4-F and EIF4-A. It binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP and promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Alias Symbols: EIF-4B, PRO1843
Protein Interaction Partner: UBC, ASB2, ZBTB1, SAMHD1, XPO7, SEC23A, PRMT3, CUL4B, USP11, SF1, XRCC5, OSBP, NARS, Stk11, CTNNA1, PARK2, FBXO6, PAN2, CSNK2A1, EIF4A3, YWHAE, MAGOH, SMURF1, NUP107, PHAX, SLC4A1AP, CCT6B, NUP153, POLR1C, RPL29, MYH9, EIF4G2, EIF4G1, EIF4A1, CSTF2, CUL3,
Protein Size: 611

Molecular Weight: 67 kDa

Gene ID: 1975

NCBI Accession: NM_001417, NP_001408

UniProt: P23588