Splicing factor U2AF 26 kDa subunit (U2AF1L4) (N-Term) antibody

Catalog No. ABIN2778747

Product Details

Target: Splicing factor U2AF 26 kDa subunit (U2AF1L4)

Binding Specificity: N-Term

Reactivity: Human, Dog, Mouse, Rat, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Sequence: KIGVCRHGDR CSRLHNKPTF SQTIVLLNLY RNPQNTAQTA DGSHCHVSDV

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 79%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against U2AF1L4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human U2AF1L4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: Splicing factor U2AF 26 kDa subunit (U2AF1L4)

Alternative Name: U2AF1L4 (U2AF1L4 Products)

Synonyms: U2 small nuclear RNA auxiliary factor 1-like protein 3 antibody, U2AF1-RS3 antibody, U2AF1-like 4 antibody, U2AF1-like protein 3 antibody, U2AF1L3 antibody, U2AF1L3V1 antibody, U2AF1RS3 antibody, U2af26 antibody, AA407033 antibody, AF419339 antibody, AI451269 antibody, AW553050 antibody, TMEM149 antibody, U2 small nuclear RNA auxiliary factor 1 like 4 antibody, U2 small nuclear RNA auxiliary factor 1-like 4 antibody, U2AF1L4 antibody, U2af1l4 antibody

Background: U2AF1L4 is a RNA-binding protein that function as a pre-mRNA splicing factor. It plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It acts by enhancing the binding of U2AF2 to weak pyrimidine tracts and also participates in the regulation of alternative pre-mRNA splicing. It activates exon 5 skipping of PTPRC during T-cell activation, an event reversed by GFI1. U2AF1L4 binds to RNA at the AG dinucleotide at the 3'-splice site.
Protein Interaction Partner: MDM2, SUZ12, UBC, ELAVL1, GIGYF2,
Protein Size: 220

Molecular Weight: 24 kDa

Gene ID: 199746

UniProt: Q8WU68