EXOSC3 antibody (C-Term)

Catalog No. ABIN2778686

Product Details anti-EXOSC3 Antibody

Target: EXOSC3 (Exosome Component 3 (EXOSC3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VIGIVTAKSG DIFKVDVGGS EPASLSYLSF EGATKRNRPN VQAISSRL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against EXOSC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EXOSC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 164 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-EXOSC3 antibody (ABIN2778686)

Fan, Huang-Liu, Shen, Ju, Lin, Pai, Huang, Ho, Tsai, Tsai, Huang: "Reduction of TLR4 mRNA stability and protein expressions through inhibiting cytoplasmic translocation of HuR transcription factor by E₂ and/or ERα in LPS-treated H9c2 cardiomyoblast cells." in: The Chinese journal of physiology, Vol. 57, Issue 1, pp. 8-18, (2014) (PubMed).

Target Details for EXOSC3

Target: EXOSC3 (Exosome Component 3 (EXOSC3))

Alternative Name: EXOSC3 (EXOSC3 Products)

Synonyms: PCH1B antibody, RP11-3J10.8 antibody, RRP40 antibody, Rrp40p antibody, bA3J10.7 antibody, hRrp-40 antibody, p10 antibody, 2310005D06Rik antibody, AI593501 antibody, Rrp40 antibody, im:7140537 antibody, zgc:112345 antibody, exosome component 3 antibody, exosome component 3 L homeolog antibody, EXOSC3 antibody, exosc3.L antibody, Exosc3 antibody, exosc3 antibody

Background: EXOSC3 is component of the exosome 3'->5' exoribonuclease complex and is required for the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA.
Alias Symbols: CGI-102, MGC15120, MGC723, RP11-3J10.8, RRP40, Rrp40p, bA3J10.7, hRrp40p, p10, hRrp-40
Protein Interaction Partner: UBC, EXOSC5, EXOSC4, CDK5RAP1, EXOSC8, ATP5D, AICDA, EXOSC10, EXOSC9, APP, EXOSC2, EXOSC6, DIS3L, EXOSC1, EXOSC3, EXOSC7, DIS3, MPHOSPH6, HDGF, KHSRP,
Protein Size: 164

Molecular Weight: 17 kDa

Gene ID: 51010

NCBI Accession: NM_001002269, NP_001002269

UniProt: Q9NQT5

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome