INSIG1 antibody (Middle Region)

Catalog No. ABIN2778634

Product Details anti-INSIG1 Antibody

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Goat, Guinea Pig, Sheep, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSIG1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: ITIAFLATLI TQFLVYNGVY QYTSPDFLYI RSWLPCIFFS GGVTVGNIGR

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against INSIG1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human INSIG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 330 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for INSIG1

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Alternative Name: INSIG1 (INSIG1 Products)

Synonyms: cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody

Background: Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane prote
Alias Symbols: CL-6, MGC1405, CL6
Protein Interaction Partner: UBC, HMGCR, FAF2, SCAP, ERLIN2, ERLIN1, VCP, AMFR, PGRMC1, POR, SREBF1, ELAVL1, RNF139, INSIG2, PSMC3, PSMA7, INSIG1, VAPA, VAPB, SREBF2,
Protein Size: 330

Molecular Weight: 36 kDa

Gene ID: 3638

NCBI Accession: NM_198336, NP_938150

UniProt: A4D2M9

Pathways: ER-Nucleus Signaling