MLX antibody (C-Term)

Catalog No. ABIN2778546

Product Details anti-MLX Antibody

Target: MLX (MAX-Like Protein X (MLX))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Goat, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LRKDVTALKI MKVNYEQIVK AHQDNPHEGE DQVSDQVKFN VFQGIMDSLF

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against MLX. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MLX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 298 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MLX antibody (ABIN2778546)

Stoltzman, Peterson, Breen, Muoio, Billin, Ayer: "Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 19, pp. 6912-7, (2008) (PubMed).

Target Details for MLX

Target: MLX (MAX-Like Protein X (MLX))

Alternative Name: MLX (MLX Products)

Synonyms: MAD7 antibody, MXD7 antibody, TCFL4 antibody, bHLHd13 antibody, Tcfl4 antibody, im:7146242 antibody, wu:fb61a01 antibody, wu:fb99c01 antibody, zgc:112409 antibody, DKFZp468J1719 antibody, MLX, MAX dimerization protein antibody, MAX-like protein X antibody, max-like protein X antibody, MLX antibody, Mlx antibody, mlx antibody, LOC786043 antibody

Background: MLX belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. MLX may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4.The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Alias Symbols: MAD7, MXD7, TCFL4, bHLHd13
Protein Interaction Partner: ZBTB32, GABARAPL2, RBM39, AES, UBC, SAP30BP, ID3, APP, SUMO1, MLXIPL, MLXIP, MXD4, MNT, MAD1L1, MLX, MXD1,
Protein Size: 298

Molecular Weight: 33 kDa

Gene ID: 6945

NCBI Accession: NM_170607, NP_733752

UniProt: Q9UH92