L3MBTL2 antibody (C-Term)

Catalog No. ABIN2778379

Product Details anti-L3MBTL2 Antibody

Target: L3MBTL2 (Lethal(3) Malignant Brain Tumor-Like Protein 2 (L3MBTL2))

Binding Specificity: C-Term

Reactivity: Human, Dog, Cow, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L3MBTL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LLEDDPQGAR KISSEPVPGE IIAVRVKEEH LDVASPDKAS SPELPVSVEN

Predicted Reactivity: Cow: 85%, Dog: 85%, Horse: 85%, Human: 100%, Pig: 92%

Characteristics: This is a rabbit polyclonal antibody against L3MBTL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human L3MBTL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 705 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-L3MBTL2 antibody (ABIN2778379)

Collins, Wright, Edwards, Davis, Grinham, Cole, Goward, Aguado, Mallya, Mokrab, Huckle, Beare, Dunham: "A genome annotation-driven approach to cloning the human ORFeome." in: Genome biology, Vol. 5, Issue 10, pp. R84, (2004) (PubMed).

Target Details for L3MBTL2

Target: L3MBTL2 (Lethal(3) Malignant Brain Tumor-Like Protein 2 (L3MBTL2))

Alternative Name: L3MBTL2 (L3MBTL2 Products)

Synonyms: L3MBTL2 antibody, im:7137244 antibody, wu:fb04e09 antibody, zgc:66491 antibody, H-l(3)mbt-l antibody, L3MBT antibody, 4732493N06Rik antibody, M4mbt antibody, L3MBTL2 polycomb repressive complex 1 subunit antibody, L3MBTL2, polycomb repressive complex 1 subunit antibody, l(3)mbt-like 2 (Drosophila) antibody, L3MBTL2 antibody, l3mbtl2 antibody, L3mbtl2 antibody

Background: L3MBTL2 contains 1 FCS-type zinc finger and 4 MBT repeats. It is putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis.
Alias Symbols: H-l(3)mbt-l, L3MBT
Protein Interaction Partner: TRIM42, STAC3, PHF10, TBC1D9B, PAICS, AES, SUMO2, SUMO1, PIAS1, HIST1H4A, HIST1H3A, RNF2, MPP3, PCGF6, RYBP, YAF2, SMARCAD1, HIST4H4, CBX3, HIST3H3, E2F6, Lin54, HDAC3, MEAF6, STAM2, RB1,
Protein Size: 705

Molecular Weight: 79 kDa

Gene ID: 83746

NCBI Accession: NM_031488, NP_113676

UniProt: Q969R5