COPS2 antibody (N-Term)

Catalog No. ABIN2778315

Product Details anti-COPS2 Antibody

Target: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Horse, Guinea Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: SDMEDDFMCD DEEDYDLEYS EDSNSEPNVD LENQYYNSKA LKEDDPKAAL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against COPS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human COPS2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 443 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COPS2

Target: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Alternative Name: COPS2 (COPS2 Products)

Synonyms: COPS2 antibody, ALIEN antibody, CSN2 antibody, SGN2 antibody, TRIP15 antibody, wu:fc05f05 antibody, wu:fc06g10 antibody, wu:fc60f04 antibody, wu:fl94f12 antibody, zgc:86624 antibody, csn2 antibody, Tb03.48O8.600 antibody, Trip15 antibody, AI315723 antibody, C85265 antibody, Csn2 antibody, Sgn2 antibody, alien-like antibody, ATCSN2 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 12 antibody, COP12 antibody, FUSCA 12 antibody, T20P8.4 antibody, T20P8_4 antibody, COP9 signalosome subunit 2 antibody, COP9 signalosome subunit 2 L homeolog antibody, COP9 signalosome complex subunit 2 antibody, COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody, proteasome family protein antibody, COPS2 antibody, cops2 antibody, cops2.L antibody, Tb927.3.2320 antibody, AOR_1_576084 antibody, PTRG_07106 antibody, LOC100283498 antibody, Cops2 antibody, csn-2 antibody, FUS12 antibody

Background: COPS2 is an essential component of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Alias Symbols: ALIEN, CSN2, SGN2, TRIP15
Protein Interaction Partner: UBC, GPS1, Map3k10, 5830415F09Rik, Taf1b, EP300, Crebbp, cul1, COPS7B, EPB41L1, COPS5, FBXW4, SENP8, vpr, IRF5, COPS4, COPS7A, COPS6, COPS8, COPS3, PMPCA, SEPHS1, EHBP1L1, SLAIN2, GAPVD1, PFKFB2, SEPT2, IRS2, GRK5, DDB2, LRR1, DCAF11, DDA1, RFWD2, DCAF8,
Protein Size: 443

Molecular Weight: 52 kDa

Gene ID: 9318

NCBI Accession: NM_004236, NP_004227

UniProt: P61201

Pathways: Cell Division Cycle