Membralin antibody (Middle Region)

Catalog No. ABIN2778282

Product Details anti-Membralin Antibody

Target: Membralin (TMEM259) (Transmembrane Protein 259 (TMEM259))

Binding Specificity: Middle Region

Reactivity: Zebrafish (Danio rerio), Human, Guinea Pig, Rat, Dog, Mouse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Membralin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: YDDILMSSVK GLAENEENKG FLRNVVSGEH YRFVSMWMAR TSYLAAFAIM

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against C19ORF6. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human C19ORF6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 408 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Membralin

Target: Membralin (TMEM259) (Transmembrane Protein 259 (TMEM259))

Alternative Name: C19ORF6 (TMEM259 Products)

Synonyms: ASBABP1 antibody, C19orf6 antibody, MBRL antibody, MEMBRALIN antibody, R32184_3 antibody, C28H19orf6 antibody, c19orf6 antibody, AC087114.7gm12 antibody, AC087114.7gm2 antibody, ORF61 antibody, mFLJ00277 antibody, Mbrl antibody, RGD1311136 antibody, transmembrane protein 259 antibody, transmembrane protein 259 L homeolog antibody, TMEM259 antibody, tmem259.L antibody, Tmem259 antibody

Background: Human membralin is unique and does not share significant sequence homology with other human genes, only membralins of other species. The membralin gene contains 11 exons which encode at least two spliced variants in human cancer. The long form of membralin (membralin-1) comprises all 11 exons, encoding a protein of 620-amino acids long and the short form of membralin (membralin-3) contains all exons except for exon 10, encoding a protein of 408 amino acids. Expression of different membralin isoforms depends on tissue type. The long form, membralin-1, is expressed in ovarian and colorectal carcinomas but not in breast or pancreatic carcinomas, which express only the short splice form, membralin-3. Recent studies suggest that membralin is a novel tumor-associated marker in ovarian serous carcinomas
Alias Symbols: MBRL, ASBABP1, R32184_3, MEMBRALIN, C19ORF6
Protein Interaction Partner: ADRB2, UBC, TMEM173, ARSE,
Protein Size: 408

Molecular Weight: 46 kDa

Gene ID: 91304

NCBI Accession: NM_033420, NP_219488