XRCC5 antibody (C-Term)
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- Target See all XRCC5 Antibodies
- XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This XRCC5 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- GITLITKEEA SGSSVTAEEA KKFLAPKDKP SGDTAAVFEE GGDVDDLLDM
- Predicted Reactivity
- Cow: 92%, Dog: 92%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against XRCC5. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human XRCC5
- Top Product
- Discover our top product XRCC5 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 732 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
- Alternative Name
- XRCC5 (XRCC5 Products)
- Synonyms
- AI314015 antibody, Ku80 antibody, Ku86 antibody, Kup80 antibody, KARP-1 antibody, KARP1 antibody, KU80 antibody, KUB2 antibody, NFIV antibody, xrcc5-a antibody, XRCC5 antibody, X-ray repair cross complementing 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog antibody, XRCC5 antibody, Xrcc5 antibody, xrcc5.L antibody
- Background
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XRCC5 encodes the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Alias Symbols: KU80, KUB2, Ku86, NFIV, KARP1, KARP-1
Protein Interaction Partner: HUWE1, UBC, EHF, ELF3, SUMO2, SUMO3, BRCA1, ATRX, Fbxl16, NEDD8, SUMO1, MDM2, RPA3, RPA2, RPA1, SUZ12, EED, RNF2, BMI1, EIF4B, C1QBP, RPL24, PLCB3, PRMT3, EIF3J, CUL2, CSDE1, SF1, TRMT1, SAMHD1, DNMBP, GANAB, HYOU1, NCL, NARS, MSH2, JUP, HSPA4, PARP1, TAR
Protein Size: 732 - Molecular Weight
- 83 kDa
- Gene ID
- 7520
- NCBI Accession
- NM_021141, NP_066964
- UniProt
- Q4VBQ5
- Pathways
- DNA Damage Repair
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