TRP63 antibody (Middle Region)

Catalog No. ABIN2778222

Product Details anti-TRP63 Antibody

Target: TRP63 (Transformation Related Protein 63 (TRP63))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rabbit, Rat, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRP63 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VTLETRDGQV LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSAKNGDGT

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against Trp63. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 461 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRP63

Target: TRP63 (Transformation Related Protein 63 (TRP63))

Alternative Name: Trp63 (TRP63 Products)

Synonyms: AI462811 antibody, Ket antibody, P51/P63 antibody, P63 antibody, P73l antibody, Tp63 antibody, Trp53rp1 antibody, transformation related protein 63 antibody, Trp63 antibody

Background: This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium.
Alias Symbols: AI462811, Ket, MGC115972, P51/P63, P63, P73l, Tp63, Trp53rp1
Protein Interaction Partner: Trp53, Dlx6, Dlx5, Abbp1, Trp73, Perp,
Protein Size: 461

Molecular Weight: 50 kDa

Gene ID: 22061

NCBI Accession: NM_001114978, NP_001108450

UniProt: Q9H3D4