KIF2A antibody (N-Term)

Catalog No. ABIN2778183

Product Details anti-KIF2A Antibody

Target: KIF2A (Kinesin Heavy Chain Member 2A (KIF2A))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: IEPSPETPPP PASSAKVNKI VKNRRTVASI KNDPPSRDNR VVGSARARPS

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against KIF2A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KIF2A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 706 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KIF2A

Target: KIF2A (Kinesin Heavy Chain Member 2A (KIF2A))

Alternative Name: KIF2A (KIF2A Products)

Synonyms: HK2 antibody, KIF2 antibody, C530030B14Rik antibody, Kif2 antibody, Kns2 antibody, M-kinesin antibody, kif2-a antibody, fj55b02 antibody, wu:fj55b02 antibody, kinesin family member 2A antibody, kinesin heavy chain member 2A L homeolog antibody, kinesin heavy chain member 2A antibody, zgc:103670 antibody, Kinesin-2 antibody, KIF2A antibody, Kif2a antibody, kif2a.L antibody, zgc:103670 antibody, GL50803_17333 antibody, GL50803_16456 antibody

Background: KIF2A belongs to the kinesin-like protein family, MCAK/KIF2 subfamily. It contains 1 kinesin-motor domain. KIF2A plus end-directed microtubule-dependent motor required for normal brain development. It may regulate microtubule dynamics during axonal growth. KIF2A is implicated in formation of bipolar mitotic spindles. It has microtubule depolymerization activity. Hela cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM].
Alias Symbols: HK2, KIF2
Protein Interaction Partner: FAM13C, MRPL53, LARP1B, KIF2A, UBC, WWOX, STK4, HIST3H3, NOTCH1, HDGF, KLC2, CLSTN1, KLC1,
Protein Size: 706

Molecular Weight: 80 kDa

Gene ID: 3796

NCBI Accession: NM_004520, NP_004511

UniProt: O00139

Pathways: Microtubule Dynamics, Ribonucleoprotein Complex Subunit Organization