PARP3 antibody (C-Term)

Catalog No. ABIN182875

Product Details anti-PARP3 Antibody

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Sequence: LGREHHINTD NPSLKSPPPG FDSVIARGHT EPDPTQDTEL ELDGQQVVVP

Predicted Reactivity: Cow: 92%, Dog: 91%, Horse: 100%, Human: 100%, Mouse: 77%, Pig: 85%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against PARP3. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PARP3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 532 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PARP3 antibody (ABIN182875)

Augustin, Spenlehauer, Dumond, Ménissier-De Murcia, Piel, Schmit, Apiou, Vonesch, Kock, Bornens, De Murcia: "PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression." in: Journal of cell science, Vol. 116, Issue Pt 8, pp. 1551-62, (2003) (PubMed).

Target Details for PARP3

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Alternative Name: PARP3 (PARP3 Products)

Background: PARP3 belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. PARP3 is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: IRT1, ADPRT3, ADPRTL2, ADPRTL3, PADPRT-3
Protein Interaction Partner: UBC, APP, PARP3, HIST1H1A, PARP1, HIST2H3C, MTHFD2, HIST2H2BE, RPA3,
Protein Size: 532

Molecular Weight: 59 kDa

Gene ID: 10039

NCBI Accession: NM_005485, NP_005476

UniProt: Q9Y6F1