FOXP2 antibody (N-Term)

Catalog No. ABIN2778104

Product Details anti-FOXP2 Antibody

Target: FOXP2 (Forkhead Box P2 (FOXP2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit, Horse, Goat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA

Specificity: Isoform 4 and 5

Predicted Reactivity: Dog: 100%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 82%

Characteristics: This is a rabbit polyclonal antibody against FOXP2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FOXP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 715 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FOXP2

Target: FOXP2 (Forkhead Box P2 (FOXP2))

Alternative Name: FOXP2 (FOXP2 Products)

Background: FOXP2 is an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Four alternative transcripts encoding three different isoforms have been identified.
Alias Symbols: SPCH1, CAGH44, TNRC10
Protein Interaction Partner: FAM124A, TSACC, RPIA, SP4, SDCBP, PIN1, CTBP2, CTBP1, CCNC, AES, MAPK3, HSP90AA1, GATAD2B, FOXP1, FOXP4, FOXP2,
Protein Size: 715

Molecular Weight: 80 kDa

Gene ID: 93986

NCBI Accession: NM_014491, NP_055306