MLL4 antibody (N-Term)

Catalog No. ABIN2778080

Product Details anti-MLL4 Antibody

Target: MLL4 (Histone-Lysine N-Methyltransferase MLL4 (MLL4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Saccharomyces cerevisiae, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: WAGPRVQRGR GRGRGRGWGP SRGCVPEEES SDGESDEEEF QGFHSDEDVA

Predicted Reactivity: Cow: 92%, Dog: 85%, Guinea Pig: 92%, Horse: 83%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against MLL4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MLL4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 582 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MLL4

Target: MLL4 (Histone-Lysine N-Methyltransferase MLL4 (MLL4))

Alternative Name: MLL4 (MLL4 Products)

Synonyms: HRX2 antibody, MLL1B antibody, MLL2 antibody, MLL4 antibody, TRX2 antibody, WBP7 antibody, 2610014H22Rik antibody, Mll2 antibody, Wbp7 antibody, mKIAA0304 antibody, ALR antibody, BC032281 antibody, BC058659 antibody, C430014K11Rik antibody, KMT2B antibody, Mll4 antibody, RGD1308331 antibody, lysine methyltransferase 2B antibody, lysine (K)-specific methyltransferase 2B antibody, lysine (K)-specific methyltransferase 2D antibody, KMT2B antibody, Kmt2b antibody, Kmt2d antibody

Background: MLL4 a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. MLL4 is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer
Alias Symbols: HRX2, MLL2, TRX2, WBP7, MLL4
Protein Interaction Partner: UBC, SMAD3, ZNF512B, ATXN1, HIST2H3C, WDR5, ASH2L, RBBP5, SEPT8, RPP14, NREP, TSC22D1, TK1, SMN1, RAP1B, PIN1, GRB7, RCC1, CDKN1A, ATP1B1, ANXA7, ANXA1, BCL6, WDR82, PAGR1, PAXIP1, NCOA6, SMARCB1, PRPF40A,
Protein Size: 582

Molecular Weight: 64 kDa

Gene ID: 9757

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Warburg Effect