TEAD4 antibody (Middle Region)

Catalog No. ABIN2777935

Product Details anti-TEAD4 Antibody

Target: TEAD4 (TEA Domain Family Member 4 (TEAD4))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: LVKFWADLNT NIEDEGSSFY GVSSQYESPE NMIITCSTKV CSFGKQVVEK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 77%

Characteristics: This is a rabbit polyclonal antibody against TEAD4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TEAD4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 391 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TEAD4 antibody (ABIN2777935)

Chan, Lim, Loo, Chong, Huang, Hong: "TEADs mediate nuclear retention of TAZ to promote oncogenic transformation." in: The Journal of biological chemistry, Vol. 284, Issue 21, pp. 14347-58, (2009) (PubMed).

Target Details for TEAD4

Target: TEAD4 (TEA Domain Family Member 4 (TEAD4))

Alternative Name: TEAD4 (TEAD4 Products)

Synonyms: TEAD4 antibody, rtef1 antibody, tef-3 antibody, eftr-2 antibody, tefr-1 antibody, tcf13l1 antibody, hrtef-1b antibody, xdtef-1 antibody, xlDTEF-1 antibody, RTEF-1 antibody, TEF-1 antibody, TEF-3 antibody, EFTR-2 antibody, RTEF1 antibody, TCF13L1 antibody, TEF3 antibody, TEFR-1 antibody, hRTEF-1B antibody, ETFR-2 antibody, Etfr2 antibody, FR-19 antibody, TEAD-4 antibody, Tcf13r1 antibody, Tef3 antibody, Tefr antibody, Tefr1 antibody, Tefr1a antibody, TEA domain transcription factor 4 antibody, TEA domain transcription factor 4 S homeolog antibody, TEA domain family member 4 antibody, TEAD4 antibody, tead4 antibody, tead4.S antibody, Tead4 antibody

Background: TEAD4 is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. TEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this protein.This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.
Alias Symbols: EFTR-2, MGC9014, RTEF1, TCF13L1, TEF-3, TEFR-1, hRTEF-1B, TEF3
Protein Interaction Partner: CCDC172, SSX2IP, LZTS2, CEP70, CEP55, RABGEF1, CCNDBP1, KIAA0753, PNMA1, TRAF1, VPS52, TRIM27, GOLGA2, UBC, SUMO2, CCDC85B, WWTR1, YAP1, VGLL1, MYH7,
Protein Size: 391

Molecular Weight: 44 kDa

Gene ID: 7004

NCBI Accession: NM_201441, NP_958849

UniProt: Q15561

Pathways: Regulation of Lipid Metabolism by PPARalpha