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T-Box 5 antibody (N-Term)

TBX5 Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Rabbit, Cow, Horse, Zebrafish (Danio rerio), Goat, Sheep WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777915
  • Target See all T-Box 5 (TBX5) Antibodies
    T-Box 5 (TBX5)
    Binding Specificity
    • 15
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 37
    • 14
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat, Dog, Guinea Pig, Rabbit, Cow, Horse, Zebrafish (Danio rerio), Goat, Sheep
    Host
    • 34
    • 3
    • 1
    Rabbit
    Clonality
    • 35
    • 3
    Polyclonal
    Conjugate
    • 21
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This T-Box 5 antibody is un-conjugated
    Application
    • 31
    • 19
    • 19
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    NSMHKYQPRL HIVKADENNG FGSKNTAFCT HVFPETAFIA VTSYQNHKIT
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against TBX5. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human TBX5
    Top Product
    Discover our top product TBX5 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 518 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Baban, Pitto, Pulignani, Cresci, Mariani, Gambacciani, Digilio, Pongiglione, Albanese: "Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation." in: American journal of medical genetics. Part A, Vol. 164A, Issue 6, pp. 1419-24, (2014) (PubMed).

    Zhang, Huang, Zuo, Chen, Wang: "Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling." in: Aquatic toxicology (Amsterdam, Netherlands), Vol. 142-143, pp. 26-32, (2013) (PubMed).

    Lu, Tsai, Choo, Yeh, Tang, Yang, Lee, Lu: "Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos." in: Journal of biomedical science, Vol. 18, pp. 73, (2011) (PubMed).

  • Target
    T-Box 5 (TBX5)
    Alternative Name
    TBX5 (TBX5 Products)
    Synonyms
    TBX5 antibody, tbx-5 antibody, xtbx-5 antibody, xtbx5 antibody, tbx5 antibody, HOS antibody, tbx5.1 antibody, zTbx5 antibody, zf-tbx5 antibody, T-box 5 antibody, T-box 5 L homeolog antibody, T-box 5a antibody, TBX5 antibody, tbx5 antibody, tbx5.L antibody, Tbx5 antibody, tbx5a antibody
    Background
    TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX5 is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in TBX5 have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for TBX5.
    Alias Symbols: HOS
    Protein Interaction Partner: KDM6A, SMARCA4, KAT5, GATA4, NKX2-5,
    Protein Size: 518
    Molecular Weight
    58 kDa
    Gene ID
    6910
    NCBI Accession
    NM_000192, NP_000183
    UniProt
    Q99593
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