EPC1 antibody (Middle Region)

Catalog No. ABIN2777875

Product Details anti-EPC1 Antibody

Target: EPC1 (Enhancer of Polycomb Homolog 1 (EPC1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rabbit, Cow, Rat, Dog, Horse, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPC1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VNKQDKADLI RPKRKYEKKP KVLPSSAAAT PQQTSPAALP VFNAKDLNQY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against EPC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EPC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 836 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EPC1

Target: EPC1 (Enhancer of Polycomb Homolog 1 (EPC1))

Alternative Name: EPC1 (EPC1 Products)

Synonyms: EPC1 antibody, Epl1 antibody, 2400007E14Rik antibody, 5730566F07Rik antibody, A930032N02Rik antibody, epc1 antibody, enhancer of polycomb homolog 1 antibody, enhancer of polycomb homolog 1 (Drosophila) a antibody, enhancer of polycomb homolog 1 (Drosophila) antibody, enhancer of polycomb homolog 1 L homeolog antibody, EPC1 antibody, epc1a antibody, Epc1 antibody, epc1 antibody, epc1.L antibody

Background: EPC1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.
Alias Symbols: DKFZp781P2312, Epl1
Protein Interaction Partner: RINT1, KRT15, Hopx, TRIM27, H2AFZ, DMAP1, ING3, MORF4L1, KAT5, MYC, MORF4L2, MRGBP, EED, EZH2, E2F6, SRF,
Protein Size: 836

Molecular Weight: 93 kDa

Gene ID: 80314

NCBI Accession: NM_025209, NP_079485

UniProt: Q9H2F5

Pathways: Regulation of Muscle Cell Differentiation