SOX10 antibody (Middle Region)

Catalog No. ABIN2777864

Product Details anti-SOX10 Antibody

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOX10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PGGEAEQGGT AAIQAHYKSA HLDHRHPGEG SPMSDGNPEH PSGQSHGPPT

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 86%

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SOX10

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 466 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SOX10 antibody (ABIN2777864)

Wilson, Olm-Shipman, Acevedo, Palaniyandi, Hall, Kosa, Stumpff, Smith, Pitstick, Liao, Bjork, Czirok, Saadi: "SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination." in: Scientific reports, Vol. 6, pp. 17735, (2016) (PubMed).

Target Details for SOX10

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Alternative Name: SOX10 (SOX10 Products)

Synonyms: DOM antibody, PCWH antibody, WS2E antibody, WS4 antibody, WS4C antibody, SOX-10 antibody, SOX10 antibody, dom antibody, ws4 antibody, Dom antibody, Sox21 antibody, SOX9 antibody, cls/sox10 antibody, zgc:100757 antibody, SRY-box 10 antibody, SRY box 10 antibody, SRY-box 10 L homeolog antibody, SRY (sex determining region Y)-box 10 antibody, SOX10 antibody, Sox10 antibody, sox10.L antibody, sox10 antibody

Background: SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
Alias Symbols: DOM, MGC15649, WS2E, WS4, PCWH, WS4C
Protein Interaction Partner: UBC, CDK6, EXOC5, NMI, EPAS1, POU3F2, UTF1, PAX3, UBE2I, OLIG2, HHEX, PAX6, ALX4, PRRX2, SUMO2, POU3F3, SUMO3, SOX10, SUMO1, TCF12, MEOX1, DLX5, HIVEP1, SP1, PRRX1, JUN, POU5F1, HOXC4, HOXA3, EGR2, CEBPA,
Protein Size: 466

Molecular Weight: 50 kDa

Gene ID: 6663

NCBI Accession: NM_006941, NP_008872

UniProt: P56693

Pathways: Chromatin Binding