SNAIL antibody (N-Term)

Catalog No. ABIN2777858

Product Details anti-SNAIL Antibody

Target: SNAIL (SNAI1)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL

Predicted Reactivity: Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SNAI1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SNAI1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 264 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SNAIL antibody (ABIN2777858)

He, Lu, Hu, Zhang, Qin, Wang, Xing, Xi, Wang: "The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation." in: International journal of molecular sciences, Vol. 16, Issue 7, pp. 16313-29, (2016) (PubMed).

Sihto, Lundin, Lundin, Lehtimäki, Ristimäki, Holli, Sailas, Kataja, Turpeenniemi-Hujanen, Isola, Heikkilä, Joensuu: "Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study." in: Breast cancer research : BCR, Vol. 13, Issue 5, pp. R87, (2012) (PubMed).

Surati, Robinson, Nandi, Faoro, Demchuk, Rolle, Kanteti, Ferguson, Hasina, Gangadhar, Salama, Arif, Kirchner, Mendonca, Campbell, Limvorasak, Villaflor, Hensing, Krausz, Vokes, Husain, Ferguson et al.: "Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database. ..." in: Journal of clinical bioinformatics, Vol. 1, Issue 8, pp. 1-11, (2011) (PubMed).

Wang, Quah, Dong, Manser, Tang, Zeng: "PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition." in: Cancer research, Vol. 67, Issue 7, pp. 2922-6, (2007) (PubMed).

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1 (SNAI1 Products)

Synonyms: SLUGH2 antibody, SNA antibody, SNAH antibody, SNAIL antibody, SNAIL1 antibody, dJ710H13.1 antibody, AI194338 antibody, Sna antibody, Sna1 antibody, Snail antibody, Snail1 antibody, SNAI1 antibody, BG:DS01845.1 antibody, CG3956 antibody, Dmel\\CG3956 antibody, Sco antibody, br28 antibody, br29 antibody, l(2)35Db antibody, l(2)br28 antibody, l(2)br29 antibody, l(3)br28 antibody, l35Db antibody, sn antibody, Xsnail antibody, sna antibody, snail1 antibody, xSna antibody, Snai antibody, sna2 antibody, snail2 antibody, cb643 antibody, sna-1 antibody, sna1 antibody, snai1 antibody, snail1a antibody, zgc:109820 antibody, snail family transcriptional repressor 1 antibody, snail family zinc finger 1 antibody, snail homolog 1 (Drosophila) antibody, snail antibody, zinc-finger transcription factor Snail antibody, snail family zinc finger 1 S homeolog antibody, protein escargot antibody, transcription factor protein antibody, snail zinc finger protein antibody, snail family zinc finger 1b antibody, snail family zinc finger 1a antibody, SNAI1 antibody, Snai1 antibody, sna antibody, snail antibody, snai1.S antibody, LOC410464 antibody, snai1b antibody, snai1a antibody

Background: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.
Alias Symbols: SNA, SNAH, SNAIL, SLUGH2, SNAIL1, dJ710H13.1
Protein Interaction Partner: MTUS2, KRT31, TRIM23, ACTN2, MID2, NOTCH2NL, KRTAP10-3, KRT40, FBXL5, EZH2, RNF2, RING1, LATS2, UBC, BTRC, TP53, MDM2, GSK3B, HDAC1, CHD4, KDM1A, HDAC3, HDAC2, RCOR1, FBXL14, NOTCH1, HIST1H3A, EGR1, AJUBA, Sin3a, HOXD4, SUZ12, CTDSP1, CTDSPL, CTDSP2, QRIC
Protein Size: 264

Molecular Weight: 29 kDa

Gene ID: 6615

NCBI Accession: NM_005985, NP_005976

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling