SOX6 antibody (Middle Region)

Catalog No. ABIN2777776

Product Details anti-SOX6 Antibody

Target: SOX6 (SRY (Sex Determining Region Y)-Box 6 (SOX6))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOX6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YGMKTDGGSL AGNEMINGED EMEMYDDYED DPKSDYSSEN EAPEAVSAN

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against SOX6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SOX6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 804 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SOX6

Target: SOX6 (SRY (Sex Determining Region Y)-Box 6 (SOX6))

Alternative Name: SOX6 (SOX6 Products)

Synonyms: HSSOX6 antibody, SOXD antibody, Sox6 antibody, AI987981 antibody, SOX-LZ antibody, fc35a10 antibody, fc50e03 antibody, sox-lz antibody, sox6b antibody, wu:fc35a10 antibody, wu:fc50e03 antibody, SRY-box 6 antibody, SRY box 6 antibody, SRY (sex determining region Y)-box 6 antibody, SOX6 antibody, Sox6 antibody, sox6 antibody

Background: SOX6 is a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. SOX6 is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. SOX6 interacts with other family members to cooperatively activate gene expression.Members of the SOX gene family, such as SOX6, encode transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes (Cohen-Barak et al., 2001 [PubMed 11255018]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2696 AL136780.1 1-2696 2697-5158 AC009869.7 10394-12855
Alias Symbols: HSSOX6, SOXD
Protein Interaction Partner: TAF4, TRIP12, UBC, SOX2, POMGNT1, ZNF184, UBE2J1, SUMO1, SUMO2, SUMO3, HDAC1, CTNNB1, SOX5, CENPK, DAZAP2, SOX6, CTBP2,
Protein Size: 804

Molecular Weight: 89 kDa

Gene ID: 55553

NCBI Accession: NM_017508, NP_059978

UniProt: A8MRT1