TDP2 antibody (Middle Region)

Catalog No. ABIN2777707

Product Details anti-TDP2 Antibody

Target: TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: IPPYYSYLKK RSSNYEIITG HEEGYFTAIM LKKSRVKLKS QEIIPFPSTK

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TTRAP. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TTRAP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 362 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TDP2 antibody (ABIN2777707)

Xu, Pan, Wang, Huang, Tian, Xue, Chen, Jia: "TTRAP is a novel PML nuclear bodies-associated protein." in: Biochemical and biophysical research communications, Vol. 375, Issue 3, pp. 395-8, (2008) (PubMed).

Target Details for TDP2

Target: TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Alternative Name: TTRAP (TDP2 Products)

Synonyms: AD022 antibody, EAP2 antibody, EAPII antibody, TTRAP antibody, dJ30M3.3 antibody, hTDP2 antibody, ad022 antibody, eap2 antibody, ttrap antibody, D13Ertd656e antibody, Ttrap antibody, tdp2 antibody, ttrapl antibody, tyrosyl-DNA phosphodiesterase 2 antibody, tyrosyl-DNA phosphodiesterase 2 S homeolog antibody, tyrosyl-DNA phosphodiesterase 2b antibody, TDP2 antibody, tdp2.S antibody, Tdp2 antibody, tdp2b antibody

Background: The TTRAP gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
Alias Symbols: TDP2, EAP2, AD022, EAPII, TTRAP, dJ30M3.3, RP1-30M3.3
Protein Interaction Partner: UBC, SRPK2, SUMO1, SUMO2, SUMO3, TAP1, SKIL, ATXN1, PSEN1, SMAD3, EPS8, DLX3, ATP5G2, C2orf88, JAM2, SNX13, AKAP9, RAB11A, PARK7, MAPK6, UBE2I, TRAF5, TRAF6, TRAF3, TRAF2, FLI1, TNFRSF1B, ETS2, ETS1, TNFRSF8, CD40, HTNVsSgp1,
Protein Size: 362

Molecular Weight: 41 kDa

Gene ID: 51567

NCBI Accession: NM_016614, NP_057698

UniProt: O95551