KDM4C antibody (C-Term)

Catalog No. ABIN2777688

Product Details anti-KDM4C Antibody

Target: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM4C antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CLCNLRGGAL KQTKNNKWAH VMCAVAVPEV RFTNVPERTQ IDVGRIPLQR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against JMJD2C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human JMJD2C

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 813 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-KDM4C antibody (ABIN2777688)

Lu, Ward, Kapoor, Rohle, Turcan, Abdel-Wahab, Edwards, Khanin, Figueroa, Melnick, Wellen, ORourke, Berger, Chan, Levine, Mellinghoff, Thompson: "IDH mutation impairs histone demethylation and results in a block to cell differentiation." in: Nature, Vol. 483, Issue 7390, pp. 474-8, (2012) (PubMed).

Target Details for KDM4C

Target: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Alternative Name: JMJD2C (KDM4C Products)

Background: JMJD2C is a member of the Jumonji domain 2 (JMJD2) family. It contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.
Alias Symbols: FLJ25949, GASC1, JHDM3C, JMJD2C, KIAA0780, bA146B14.1
Protein Interaction Partner: UBC, HIST2H3C, HDAC3, PPARG, HDAC1, H3F3A, HIST1H3A, KDM4C, KDM4A,
Protein Size: 813

Molecular Weight: 92 kDa

Gene ID: 23081

NCBI Accession: NM_001146695, NP_001140167

UniProt: F5H347

Pathways: Nuclear Hormone Receptor Binding, Warburg Effect