Hairless antibody (Middle Region)

Catalog No. ABIN2777657

Product Details anti-Hairless Antibody

Target: Hairless (HR)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hairless antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RVWAPGDAGQ QKESTQKTPP TPQPSCNGDT HRTKSIKEET PDSAETPAED

Predicted Reactivity: Cow: 77%, Dog: 85%, Human: 100%, Mouse: 77%, Pig: 85%, Rat: 77%

Characteristics: This is a rabbit polyclonal antibody against HR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1189 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Hairless

Target: Hairless (HR)

Alternative Name: HR (HR Products)

Synonyms: ALUNC antibody, AU antibody, HSA277165 antibody, MUHH antibody, MUHH1 antibody, HR antibody, N antibody, ba antibody, bldy antibody, hr antibody, rh antibody, rh-bmh antibody, rhino antibody, HR, lysine demethylase and nuclear receptor corepressor antibody, hairless antibody, HR antibody, Hr antibody

Background: HR is a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Mutations in this gene have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions.This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Mutations in this gene have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ALUNC, AU, HSA277165, MUHH, MUHH1
Protein Interaction Partner: VDR, TBL1X, TRIM27, RARB, RARA, HDAC1, HDAC5, HDAC3, HMGB1, HDAC2, THRA,
Protein Size: 1189

Molecular Weight: 127 kDa

Gene ID: 55806

NCBI Accession: NM_005144, NP_005135

UniProt: O43593