FOXN3 antibody (C-Term)

Catalog No. ABIN2777625

Product Details anti-FOXN3 Antibody

Target: FOXN3 (Forkhead Box N3 (FOXN3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Guinea Pig, Horse, Rat, Dog, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXN3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SGYASQHKKR QHFAKARKVP SDTLPLKKRR TEKPPESDDE EMKEAAGSLL

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CHES1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CHES1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 468 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FOXN3 antibody (ABIN2777625)

Huot, Vernier, Bourdeau, Doucet, Saint-Germain, Gaumont-Leclerc, Moro, Ferbeyre: "CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis." in: Molecular biology of the cell, Vol. 25, Issue 5, pp. 554-65, (2014) (PubMed).

Target Details for FOXN3

Target: FOXN3 (Forkhead Box N3 (FOXN3))

Alternative Name: CHES1 (FOXN3 Products)

Background: Checkpoint suppressor 1 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway.
Alias Symbols: CHES1, PRO1635, C14orf116
Protein Interaction Partner: EXOSC8, SRPK2, ELAVL1, MEN1,
Protein Size: 468

Molecular Weight: 52 kDa

Gene ID: 1112

NCBI Accession: NM_005197, NP_005188

UniProt: O00409