MXD4 antibody (N-Term)

Catalog No. ABIN2777585

Product Details anti-MXD4 Antibody

Target: MXD4 (MAX Dimerization Protein 4 (MXD4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rabbit, Sheep, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MXD4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Sequence: SLLILLEAAE YLERRDREAE HGYASVLPFD GDFAREKTKA AGLVRKAPNN

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against MXD4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MXD4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 209 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MXD4

Target: MXD4 (MAX Dimerization Protein 4 (MXD4))

Alternative Name: MXD4 (MXD4 Products)

Synonyms: MAD4 antibody, MST149 antibody, MSTP149 antibody, bHLHc12 antibody, xmad4 antibody, mst149 antibody, bhlhc12 antibody, mstp149 antibody, MGC84841 antibody, MXD4 antibody, 2810410A03Rik antibody, Mad4 antibody, MAX dimerization protein 4 antibody, Max dimerization protein 4 antibody, MAX dimerization protein 4 S homeolog antibody, microRNA 4800 antibody, MXD4 antibody, Mxd4 antibody, mxd4.S antibody, MIR4800 antibody, mxd4 antibody

Background: MXD4 is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
Alias Symbols: MAD4, MST149, MSTP149, bHLHc12
Protein Interaction Partner: TCP10L, UBC, SHBG, SIN3A, MLX, MAX, SMC3,
Protein Size: 209

Molecular Weight: 24 kDa

Gene ID: 10608

NCBI Accession: NM_006454, NP_006445

UniProt: Q14582