PAX7 antibody (C-Term)

Catalog No. ABIN2777560

Product Details anti-PAX7 Antibody

Target: PAX7 (Paired Box 7 (PAX7))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Cow, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAX7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: QADFSISPLH GGLDSATSIS ASCSQRADSI KPGDSLPTSQ AYCPPTYSTT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against PAX7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of PAX7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 520 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PAX7 antibody (ABIN2777560)

Gautam, Nirwane, Yao: "Laminin differentially regulates the stemness of type I and type II pericytes." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 28, (2017) (PubMed).

Czerwinska, Nowacka, Aszer, Gawrzak, Archacka, Fogtman, Iwanicka-Nowicka, Jańczyk-Ilach, Koblowska, Ciemerych, Grabowska: "Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 21, pp. 2931-2942, (2016) (PubMed).

Wehling-Henricks, Li, Lindsey, Wang, Welc, Ramos, Khanlou, Kuro-O, Tidball: "Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy." in: Human molecular genetics, Vol. 25, Issue 12, pp. 2465-2482, (2016) (PubMed).

Akahori, Karmali, Polavarapu, Lyle, Weiss, Shin, Husain, Naqvi, Van Dam, Habib, Choi, King, Pachura, Taylor, Lefer, Finn: "CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury." in: Nature communications, Vol. 6, pp. 7792, (2015) (PubMed).

McDonald, Hebert, McLoon: "Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis." in: Neuromuscular disorders : NMD, Vol. 25, Issue 11, pp. 873-87, (2015) (PubMed).

Caldow, Thomas, Dale, Tomkinson, Buckley, Cameron-Smith: "Early myogenic responses to acute exercise before and after resistance training in young men." in: Physiological reports, Vol. 3, Issue 9, (2015) (PubMed).

Target Details for PAX7

Target: PAX7 (Paired Box 7 (PAX7))

Alternative Name: PAX7 (PAX7 Products)

Synonyms: PAX7 antibody, HUP1 antibody, PAX7B antibody, RMS2 antibody, pax-7 antibody, PAX-7 antibody, RGD1564360 antibody, Pax-7 antibody, pax7 antibody, pax7c antibody, pax7d antibody, pax7e antibody, paired box 7 antibody, paired box protein Pax-7 antibody, paired box 7 L homeolog antibody, paired box 7a antibody, PAX7 antibody, pax7.L antibody, LOC536229 antibody, Pax7 antibody, pax7a antibody

Background: PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box gene 7 is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown.
Alias Symbols: FLJ37460, HUP1, PAX7B, RMS2
Protein Interaction Partner: TRIM27, MYOD1, Dlg4, WDR5, ASH2L, HIRA, Ubc,
Protein Size: 520

Molecular Weight: 57 kDa

Gene ID: 5081

NCBI Accession: NM_002584, NP_002575

UniProt: P23759