MBD1 antibody (C-Term)
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- Target See all MBD1 Antibodies
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MBD1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- EEDKEENKDD SASKLAPEEE AGGAGTPVIT EIFSLGGTRF RDTAVWLPRS
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MBD1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product MBD1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 629 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
- Alternative Name
- MBD1 (MBD1 Products)
- Synonyms
- CXXC3 antibody, PCM1 antibody, RFT antibody, Cxxc3 antibody, CCDC11 antibody, methyl-CpG binding domain protein 1 antibody, MBD1 antibody, Mbd1 antibody
- Background
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The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions, several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides, transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Alias Symbols: CXXC3, PCM1, RFT
Protein Interaction Partner: SUMO1, HTT, UBC, ECT2, APP, ATXN1L, TENM1, SUMO2, HIST1H3A, PCNA, ATF7IP2, ATF7IP, CHAF1A, SETDB1, PIAS1, STAT1, PRAM1, HDAC3, PIAS2, ZNF512B, Rnf2, CBX4, CBX5, HIPK3, SMAD9, OASL, SMAD5, SMAD3, SMAD7, SMAD1, SUV39H1,
Protein Size: 629 - Molecular Weight
- 69 kDa
- Gene ID
- 4152
- NCBI Accession
- NM_001204138, NP_001191067
- UniProt
- Q9UIS9
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