HOXD3 antibody (Middle Region)

Catalog No. ABIN2777522

Product Details anti-HOXD3 Antibody

Target: HOXD3 (Homeobox D3 (HOXD3))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOXD3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AHKGAELNGS CMRPGTGNSQ GGGGGSQPPG LNSEQQPPQP PPPPPTLPPS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HOXD3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HOXD3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 432 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HOXD3 antibody (ABIN2777522)

Kodama, Sakai, Murakami, Murai, Mori, Maruo, Yanai, Masegi: "Immunohistochemical demonstration of angiogenesis-associated homeobox proteins in canine vascular tumours." in: Journal of comparative pathology, Vol. 141, Issue 2-3, pp. 199-203, (2009) (PubMed).

Kodama, Sakai, Matsuura, Murakami, Murai, Mori, Maruo, Kimura, Masegi, Yanai: "Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes." in: BMC cancer, Vol. 9, pp. 363, (2009) (PubMed).

Target Details for HOXD3

Target: HOXD3 (Homeobox D3 (HOXD3))

Alternative Name: HOXD3 (HOXD3 Products)

Synonyms: HOX1D antibody, HOX4 antibody, HOX4A antibody, Hox-4.1 antibody, Hox-5.5 antibody, Z-56 antibody, hoxd3 antibody, im:7144208 antibody, Hox4r6 antibody, HOXD3 antibody, hox4 antibody, hox1d antibody, hox4a antibody, hox-4.1 antibody, HoxD3a antibody, HOXD3A antibody, homeobox D3 antibody, homeobox D3a antibody, homeo box D3 antibody, homeobox D3 L homeolog antibody, HOXD3 antibody, Hoxd3 antibody, hoxd3a antibody, hoxd3.L antibody, hoxd3 antibody

Background: HOXD3 (homeobox D3) belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that remove the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. HOXD3 may play a role in the regulation of cell adhesion processes.
Alias Symbols: HOX1D, HOX4, HOX4A, Hox-4.1, MGC10470
Protein Interaction Partner: Hoxa1, ALX4, DDB1, HMGB1,
Protein Size: 432

Molecular Weight: 46 kDa

Gene ID: 3232

NCBI Accession: NM_006898, NP_008829

UniProt: P31249