FOXA3 antibody (Middle Region)

Catalog No. ABIN2777513

Product Details anti-FOXA3 Antibody

Target: FOXA3 (Forkhead Box A3 (FOXA3))

Binding Specificity: Middle Region

Reactivity: Human, Dog, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXA3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: FENGCYLRRQ KRFKLEEKVK KGGSGAATTT RNGTGSAAST TTPAATVTSP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against FOXA3. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FOXA3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 350 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FOXA3 antibody (ABIN2777513)

Menga, Infantino, Iacobazzi, Convertini, Palmieri, Iacobazzi: "Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier." in: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 23, Issue 8, pp. 978-87, (2013) (PubMed).

Target Details for FOXA3

Target: FOXA3 (Forkhead Box A3 (FOXA3))

Alternative Name: FOXA3 (FOXA3 Products)

Synonyms: FOXA3 antibody, Zffkh1 antibody, fa11c04 antibody, fkd2 antibody, forkhead-2 antibody, wu:fa11c04 antibody, wu:fc37a08 antibody, zf-FKH1 antibody, FKHH3 antibody, HNF3G antibody, TCF3G antibody, HNF3-G antibody, Hnf-3g antibody, Hnf3g antibody, Tcf-3g antibody, Tcf3g antibody, forkhead box A3 antibody, FOXA3 antibody, foxa3 antibody, Foxa3 antibody

Background: FOXA3 encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
Alias Symbols: FKHH3, HNF3G, TCF3G
Protein Interaction Partner: PPARA, ALX4, TLE2, TLE1, HMGB1,
Protein Size: 350

Molecular Weight: 37 kDa

Gene ID: 3171

NCBI Accession: NM_004497, NP_004488

UniProt: P55318

Pathways: Carbohydrate Homeostasis