MECOM antibody (C-Term)

Catalog No. ABIN2777403

Product Details anti-MECOM Antibody

Target: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MECOM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: HFTDSLKMRK MEDNQYSEAE LSSFSTSHVP EELKQPLHRK SKSQAYAMML

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against EVI1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EVI1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1051 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MECOM

Target: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Alternative Name: EVI1 (MECOM Products)

Synonyms: AML1-EVI-1 antibody, EVI1 antibody, MDS1 antibody, MDS1-EVI1 antibody, PRDM3 antibody, D630039M04Rik antibody, Evi-1 antibody, Evi1 antibody, Jbo antibody, Mds antibody, Mds1 antibody, Mds1-Evi1 antibody, Prdm3 antibody, Znfpr1b1 antibody, evi1 antibody, im:7140716 antibody, prdm3 antibody, evi-1 antibody, mecom antibody, mecom-a antibody, mecom-b antibody, xEvi-1 antibody, evi1-B antibody, MDS1 and EVI1 complex locus antibody, MDS1 and EVI1 complex locus L homeolog antibody, MDS1 and EVI1 complex locus S homeolog antibody, MECOM antibody, Mecom antibody, mecom antibody, mecom.L antibody, mecom.S antibody

Background: EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity.
Alias Symbols: AML1-EVI-1, EVI-1, MDS1-EVI1, MGC163392, PRDM3, EVI1, MDS1
Protein Interaction Partner: PRMT1, PIAS4, SUMO1, SOX2, ELAVL1, SIRT1, KAT2B, SMAD4, SMAD3, SMAD2, SMAD1, EHMT2, SUV39H1, MECOM, HDAC1, HDAC4, CTBP2, CTBP1, CREBBP, MBD3,
Protein Size: 1051

Molecular Weight: 118 kDa

Gene ID: 2122

NCBI Accession: NM_005241, NP_005232

UniProt: Q03112