ESRRG antibody (Middle Region)

Catalog No. ABIN2777400

Product Details anti-ESRRG Antibody

Target: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESRRG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RIDAENSPYL NPQLVQPAKK PYNKIVSHLL VAEPEKIYAM PDPTVPDSDI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against ESRRG. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ESRRG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 458 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ESRRG antibody (ABIN2777400)

Song, Wang: "A conserved gene structure and expression regulation of miR-433 and miR-127 in mammals." in: PLoS ONE, Vol. 4, Issue 11, pp. e7829, (2009) (PubMed).

Song, Wang: "Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma." in: Nucleic acids research, Vol. 36, Issue 18, pp. 5727-35, (2008) (PubMed).

Target Details for ESRRG

Target: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Alternative Name: ESRRG (ESRRG Products)

Background: ERRs, which are coexpressed with ERs in prostatic cells, could regulate cell growth and modulate ER-mediated pathways via interference on ERalpha transcription in prostatic cells. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis. Transcriptional activation by ERR3 can be ligand-independent.
Alias Symbols: ERR3, NR3B3, ERRgamma
Protein Interaction Partner: MEOX2, KIFC3, ESRRG, NR0B1, SUMO1P1, CCDC67, KIAA1598, NUP160, SRPK1, SRA1, PPARGC1A, APP, PNRC2, NR0B2, TLE1, ESRRA, EIF3I, NRIP1, SRC, PROX1, DUT, ARHGEF15, PNRC1, EBP, UBC, PARK2, DPF2, SP1, PPARGC1B, DAXX, NCOA1, CALM1, HGS,
Protein Size: 458

Molecular Weight: 51 kDa

Gene ID: 2104

NCBI Accession: NM_206595, NP_996318

UniProt: P62508

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway