IKZF1 antibody (Middle Region)

Catalog No. ABIN2777317

Product Details anti-IKZF1 Antibody

Target: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKZF1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DLCKIGSERS LVLDRLASNV AKRKSSMPQK FLGDKGLSDT PYDSSASYEK

Predicted Reactivity: Cow: 92%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 92%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against IKZF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IKZF1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 519 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IKZF1

Target: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Alternative Name: IKZF1 (IKZF1 Products)

Synonyms: Hs.54452 antibody, IK1 antibody, IKAROS antibody, LYF1 antibody, PRO0758 antibody, ZNFN1A1 antibody, hIk-1 antibody, RGD1562979 antibody, ikaros antibody, znfn1a1 antibody, ik1 antibody, lyf1 antibody, hik-1 antibody, pro0758 antibody, hs.54452 antibody, MGC108252 antibody, 5832432G11Rik antibody, Ikaros antibody, LyF-1 antibody, Zfpn1a1 antibody, Znfn1a1 antibody, hlk-1 antibody, mKIAA4227 antibody, ikzf1 antibody, IKAROS family zinc finger 1 antibody, IKAROS family zinc finger 1 (Ikaros) antibody, IKZF1 antibody, Ikzf1 antibody, ikzf1 antibody

Background: IKZF1 binds and activates the enhancer (delta-A element) of the CD3-delta gene. It functions in the specification and the maturation of the T-lymphocyte. It also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development.
Alias Symbols: Hs.54452, IK1, IKAROS, LYF1, PRO0758, ZNFN1A1, hIk-1
Protein Interaction Partner: PRKAB2, PIN1, FGF12, DDX6, DCX, CTBP2, CTBP1, CKS1B, BYSL, FAM74A4, C1orf174, CEP57L1, ALKBH3, ZMAT2, ZNF417, FRMD6, SPATC1L, FAM161A, FAM214B, ARMC7, NOC4L, SCNM1, C8orf33, AEN, GMCL1P1, KIF9, SH2D4A, CBX8, LMO3, C19orf66, C1orf109, SYT17, ZNF581, FAM50B
Protein Size: 519

Molecular Weight: 57 kDa

Gene ID: 10320

NCBI Accession: NM_006060, NP_006051

UniProt: Q13422

Pathways: Production of Molecular Mediator of Immune Response