TH antibody (N-Term)

Catalog No. ABIN2777174

Product Details anti-TH Antibody

Target: TH

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TH antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GAPGPSLTGS PWPGTAAPAA SYTPTPRSPR FIGRRQSLIE DARKEREAAV

Predicted Reactivity: Cow: 91%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against TH. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of human TH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 528 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TH

Target: TH

Abstract: TH Products

Background: The specific function of the protein remains unknown. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Alias Symbols: TYH, DYT14, DYT5b
Protein Interaction Partner: TYSND1, YWHAQ, MAPKAPK2, CDK11B, RPS6KA5, CAMK2G, MAPK3, PRKACA, YWHAB, YWHAZ, MAPK1, SNCA, CSNK2A1,
Protein Size: 528

Molecular Weight: 58 kDa

Gene ID: 7054

NCBI Accession: NM_199292, NP_954986

UniProt: P07101