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MMP3 antibody (Middle Region)

MMP3 Reactivity: Human, Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777122
  • Target See all MMP3 Antibodies
    MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))
    Binding Specificity
    • 15
    • 9
    • 8
    • 8
    • 8
    • 8
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 132
    • 51
    • 47
    • 17
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse
    Host
    • 111
    • 38
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 104
    • 49
    Polyclonal
    Conjugate
    • 91
    • 12
    • 11
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MMP3 antibody is un-conjugated
    Application
    • 110
    • 66
    • 62
    • 31
    • 29
    • 23
    • 16
    • 13
    • 13
    • 11
    • 9
    • 7
    • 5
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    AEDFPGIDSK IDAVFEEFGF FYFFTGSSQL EFDPNAKKVT HTLKSNSWLN
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against MMP3. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human MMP3
    Top Product
    Discover our top product MMP3 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 477 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Stickel, Osterreicher, Halangk, Berg, Homann, Hellerbrand, Patsenker, Schneider, Kolb, Friess, Schuppan, Puhl, Seitz, Leathart, Day: "No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease." in: Alcoholism, clinical and experimental research, Vol. 32, Issue 6, pp. 959-65, (2008) (PubMed).

  • Target
    MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))
    Alternative Name
    MMP3 (MMP3 Products)
    Synonyms
    CHDS6 antibody, MMP-3 antibody, SL-1 antibody, STMY antibody, STMY1 antibody, STR1 antibody, SLN-1 antibody, SLN1 antibody, STR-1 antibody, Stmy1 antibody, Str1 antibody, MMP10 antibody, chds6 antibody, mmp-3 antibody, mmp13 antibody, mmp3 antibody, sl-1 antibody, stmy antibody, stmy1 antibody, str1 antibody, matrix metallopeptidase 3 antibody, matrix metallopeptidase 3 (stromelysin 1, progelatinase) antibody, matrix metallopeptidase 3 L homeolog antibody, MMP3 antibody, Mmp3 antibody, mmp3.L antibody
    Background
    MMP3 can degrade fibronectin, laminin, gelatins of type I, III, IV, and V, collagens III, IV, X, and IX, and cartilage proteoglycans. MMP3 activates procollagenase.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1, CHDS6
    Protein Interaction Partner: MEOX2, SPOCK3, SPOCK1, TNFSF11, CCL8, CCL13, BCAN, TIMP1, TIMP3, MMP3, SERPINE1, PLG, SPP1, CCL7, CCL2, ACAN, IGFBP3, DCN, HAPLN1,
    Protein Size: 477
    Molecular Weight
    43 kDa
    Gene ID
    4314
    NCBI Accession
    NM_002422, NP_002413
    UniProt
    P08254
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