APCS antibody (N-Term)
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- Target See all APCS Antibodies
- APCS (Amyloid P Component, Serum (APCS))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APCS antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- NFTLCFRAYS DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT
- Predicted Reactivity
- Guinea Pig: 86%, Human: 100%, Mouse: 77%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against APCS. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human APCS
- Top Product
- Discover our top product APCS Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 223 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q." in: Neurobiology of disease, Vol. 19, Issue 1-2, pp. 273-82, (2005) (PubMed).
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Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q." in: Neurobiology of disease, Vol. 19, Issue 1-2, pp. 273-82, (2005) (PubMed).
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- Target
- APCS (Amyloid P Component, Serum (APCS))
- Alternative Name
- APCS (APCS Products)
- Synonyms
- PTX2 antibody, SAP antibody, Sap antibody, APCS antibody, FP antibody, SAP(FP) antibody, apcs antibody, ptx2 antibody, sap antibody, amyloid P component, serum antibody, serum amyloid P-component antibody, amyloid P component, serum protein L homeolog antibody, APCS antibody, Apcs antibody, apcs.L antibody
- Background
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APCS is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. This gene has multiple polyadenylation sites.
Alias Symbols: MGC88159, PTX2, SAP
Protein Interaction Partner: COPS5, GK, HES1, GRB2, GOT2, FCGR3B, FCGR2B, CALU, TG, LAMA1, FCGR1A, FCGR3A, FN1, CRP, C4BPA, C1QA, COL4A1, APCS,
Protein Size: 223 - Molecular Weight
- 25 kDa
- Gene ID
- 325
- NCBI Accession
- NM_001639, NP_001630
- UniProt
- P02743
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