OXT antibody (N-Term)

Catalog No. ABIN2777015

Product Details anti-OXT Antibody

Target: OXT (Oxytocin, Prepropeptide (OXT))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Guinea Pig, Horse, Rabbit, Sheep, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OXT antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG RCFGPNICCA

Predicted Reactivity: Cow: 85%, Dog: 92%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 86%, Rat: 93%, Sheep: 85%

Characteristics: This is a rabbit polyclonal antibody against OXT. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 125 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for OXT

Target: OXT (Oxytocin, Prepropeptide (OXT))

Alternative Name: OXT (OXT Products)

Synonyms: OT antibody, OT-NPI antibody, OXT-NPI antibody, Oxy antibody, OTNPI antibody, NEURL1 antibody, RNF67 antibody, bA416N2.1 antibody, neu antibody, neu-1 antibody, Ocytocin antibody, Oxytocin antibody, oxytocin/neurophysin I prepropeptide antibody, oxytocin antibody, oxytocin/neurophysin 1 prepropeptide antibody, neuralized E3 ubiquitin protein ligase 1 antibody, vasopressin-neurophysin 2 antibody, OXT antibody, Oxt antibody, NEURL1 antibody, LOC100066842 antibody

Background: There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
Alias Symbols: MGC126890, MGC126892, OT, OT-NPI
Protein Interaction Partner: TXNDC17, ESR2, PREP, OXTR, KMT2A,
Protein Size: 125

Molecular Weight: 9 kDa

Gene ID: 5020

NCBI Accession: NM_000915, NP_000906

UniProt: P01178

Pathways: Myometrial Relaxation and Contraction, Feeding Behaviour