DPYS antibody (N-Term)

Catalog No. ABIN2776832

Product Details anti-DPYS Antibody

Target: DPYS (Dihydropyrimidinase (DPYS))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYS antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VLDAAGKLVL PGGIDTHTHM QFPFMGSRSI DDFHQGTKAA LSGGTTMIID

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against DPYS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DPYS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 519 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-DPYS antibody (ABIN2776832)

Thomas, Chen, Lin, Tomlinson, Lam, Liu, Yeung, Chan, Wong: "Middle cerebral artery stenosis increased the risk of vascular disease mortality among type 2 diabetic patients." in: Cerebrovascular diseases (Basel, Switzerland), Vol. 25, Issue 3, pp. 261-7, (2008) (PubMed).

Thomas, Ezzeldin, Guarcello, Mattison, Fridley, Diasio: "Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism." in: Pharmacogenetics and genomics, Vol. 18, Issue 1, pp. 25-35, (2008) (PubMed).

Target Details for DPYS

Target: DPYS (Dihydropyrimidinase (DPYS))

Alternative Name: DPYS (DPYS Products)

Synonyms: DHP antibody, DHPase antibody, 1200017I10Rik antibody, 1300004I01Rik antibody, dhp antibody, dihydropyrimidinase antibody, dihydropyrimidinase L homeolog antibody, DPYS antibody, Dpys antibody, Jann_1488 antibody, hydA antibody, h16_A3075 antibody, Veis_0725 antibody, AZC_1966 antibody, M446_2543 antibody, RSKD131_3628 antibody, Vapar_5601 antibody, Rleg_5687 antibody, LOC9307588 antibody, EIO_3239 antibody, blr3333 antibody, BAV0676 antibody, hyuA antibody, CtCNB1_2936 antibody, dpyS antibody, Pat9b_1914 antibody, dpys antibody, dpys.L antibody

Background: Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
Alias Symbols: DHP, DHPase
Protein Interaction Partner: DPYSL5,
Protein Size: 519

Molecular Weight: 56 kDa

Gene ID: 1807

NCBI Accession: NM_001385, NP_001376

UniProt: Q14117