MSH2 antibody (N-Term)
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- Target See all MSH2 Antibodies
- MSH2 (Mismatch Repair Protein 2 (MSH2))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Dog, Guinea Pig, Zebrafish (Danio rerio), Cow, Horse, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MSH2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- GNKASKENDW YLAYKASPGN LSQFEDILFG NNDMSASIGV VGVKMSAVDG
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%
- Characteristics
- This is a rabbit polyclonal antibody against MSH2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human MSH2
- Top Product
- Discover our top product MSH2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 934 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study." in: BMC cancer, Vol. 8, pp. 322, (2009) (PubMed).
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Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study." in: BMC cancer, Vol. 8, pp. 322, (2009) (PubMed).
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- Target
- MSH2 (Mismatch Repair Protein 2 (MSH2))
- Alternative Name
- MSH2 (MSH2 Products)
- Synonyms
- COCA1 antibody, FCC1 antibody, HNPCC antibody, HNPCC1 antibody, LCFS2 antibody, AI788990 antibody, wu:fc06b02 antibody, wu:fc13e09 antibody, zgc:55333 antibody, ATMSH2 antibody, MUTS homolog 2 antibody, msh2 antibody, mutS homolog 2 antibody, mutS homolog 2 (E. coli) antibody, MUTS homolog 2 antibody, mutS homolog 2 L homeolog antibody, MutS protein homolog 2 antibody, MSH2 antibody, Msh2 antibody, msh2 antibody, msh2.L antibody
- Background
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MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Protein Interaction Partner: ESR1, BRCA1, SUMO2, RPA3, RPA2, RPA1, REV1, POLK, DPYSL3, ATP6V1B2, CUL2, XRCC5, SUPT5H, STAT3, ST13, PDE3A, NRD1, JUP, XRCC6, SEC23A, HDAC6, PCNA, MSH3, MSH6, ERCC4, ERCC1, gag-pol, UBC, SUPT16H, SEPT9, SRSF10, SRSF11, SART1, SMARCA5, TOP2B, SRSF7, SRSF5
Protein Size: 934 - Molecular Weight
- 105 kDa
- Gene ID
- 4436
- NCBI Accession
- NM_000251, NP_000242
- UniProt
- P43246
- Pathways
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
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